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CSF1R 抗体

This anti-CSF1R antibody is a 大鼠 单克隆 antibody detecting CSF1R in FACS 和 Func. Suitable for 小鼠 和 大鼠.
产品编号 ABIN317381
发货至: 中国

Quick Overview for CSF1R 抗体 (ABIN317381)

抗原

See all CSF1R 抗体
CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

适用

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小鼠, 大鼠

宿主

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大鼠

克隆类型

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单克隆

标记

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This CSF1R antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Functional Studies (Func)

克隆位点

604B5 2E11
  • 特异性

    This antibody recognizes the Murine CD115 cell surface antigen, also known as the M-CSF receptor and as c-fms. This antibody has been shown to inhibit in vitro colony formation in response to M-CSF in both rats and mice.

    产品特性

    Synonyms: CSF-1-R, Fms proto-oncogene, c-fms, CSF1R, FMS, Macrophage colony-stimulating factor 1receptor

    纯化方法

    Purified IgG prepared by ion exchange chromatography

    免疫原

    RAW 264 cells. Spleen cells from immunised Sprague Dawley rats were fused with cells of the P3-653myeloma cell line.

    亚型

    IgG1
  • 应用备注

    Functional Assays. Flow Cytometry: Use 10 μL of 1/10-1/100 diluted antibody to label 10^6 cells in 100 μL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    PBS, pH 7.4, None, None

    储存液

    Without preservative

    储存条件

    -20 °C

    储存方法

    Store the antibody undiluted at -20 °C. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.

    有效期

    12 months
  • 抗原

    CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

    别名

    CD115

    背景

    This protein tyrosine kinase transmembrane receptor is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a member of the CSF1/PDGF receptor family of tyrosine protein kinases and contains 5 immunoglobulin like C2 type domains. CD115 is expressed by cells of the monocytic lineage and by progenitor cells. Mutations in this gene have been associated with a predisposition to myeloid malignancy.Synonyms: CSF-1-R, CSF1R, FMS, Fms proto-oncogene, Macrophage colony-stimulating factor 1 receptor, c-fms

    基因ID

    12978

    UniProt

    P09581

    途径

    RTK signaling, Inositol Metabolic Process, Cell-Cell Junction Organization
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